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North American Pharmacist Licensure Examination Question and Answers

North American Pharmacist Licensure Examination

Last Update May 18, 2024
Total Questions : 154

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Questions 1

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA.

His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includes Dexamethasone 8 mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V, Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10 mg suppository daily prn for constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mg po bid, D51/2NS with 20K at 125mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose 0.1 mg. lock-out every 6min, one hour limit 2.2 mg/hour. Pertinent morning labs includes serum creatinine 1.4 mg/dl, Mg 1.5 mg/dl, K 5.0 mmol/L, Na 135 mmol/L.

Which of the following medication may significantly cause QT prolongation?

Options:

A.  

Lisinopril

B.  

Levothyroxine

C.  

Metformin

D.  

Hydromorphone

E.  

Citalopram

Discussion 0
Questions 2

A 27-year-old female with ovarian cancer is undergoing chemotherapy. She develops subsequent renal failure.

Which of the following drugs is most likely responsible for this?

Options:

A.  

Cyclophosphamide

B.  

Bleomycin

C.  

Cisplatin

D.  

Vinblastine

E.  

Vincristine

Discussion 0
Questions 3

RL is a 54 YOM who’s calculated 10-year atherosclerotic cardiovascular disease (ASCVD) risk is 18 %.

Which of the following is the most appropriate pharmacotherapy recommendation for CR?

Options:

A.  

Rosuvastatin 10 mg PO QHS

B.  

Atorvastatin 80 mg PO QHS

C.  

Lovastatin 10 mg PO QHS

D.  

Pravastatin 20 mg PO QHS

E.  

Atorvastatin 20mg PO QHS

Discussion 0
Questions 4

What is the standard oral weekly dose of alendronate given to treat osteoporosis?

Options:

A.  

10mg

B.  

70mg

C.  

140mg

D.  

200mg

Discussion 0
Questions 5

You prescribe doxepin to a 37-year-old woman to treat neurotic excoriations on her arms. The patient is concerned about the side effects of this drug. Which of the following is not a side effect of doxepin:

Options:

A.  

Xerostomia

B.  

Liver toxicity

C.  

Somnolence

D.  

Urinary retention

E.  

Constipation

Discussion 0
Questions 6

A Physician orders amiodarone 1 mg/min for six hours, then 0.5 mg/min thereafter. The patient’s weight is 156 lbs. The concentration of the IV bag comes as 1.8 mg per ml. Calculate the infusion rate in mL/hr.

Options:

A.  

33.33mls/hr then /16.67mls/hr

B.  

60mls/hr then 30mls/hr

C.  

30mls/hr then 15mls/hr

D.  

16.67mls/hr then 8.3mls/hr

E.  

8.3mls/hr then 4.15mls/hr

Discussion 0
Questions 7

WM did not receive influenza vaccine prior to the start of this season, it’s now December. He did get influenza vaccine last year. Which of the following is correct course of action?

Options:

A.  

Skip influenza vaccine for this year since it’s too late.

B.  

Skip influenza vaccine for this year since he received vaccine last year.

C.  

Start WM on Tamiflu to prevent him from getting influenza.

D.  

Vaccinate him with influenza vaccine since influenza season lasts until March in your community.

E.  

Start Amantadine 200mg daily

Discussion 0
Questions 8

A physician orders Dopamine 5 mcg/kg/min. The concentration of the Dopamine IV bag is 400 mg in 250 D5W. The patient’s weight is 168 lbs. Calculate the infusion rate in mL/hr.

Options:

A.  

10.2mls/hr

B.  

5.2mls/hr

C.  

14.29mls/hr

D.  

22.4mls/hr

E.  

0.17mls/hr

Discussion 0
Questions 9

You need 51.3 mEq of NaCl to make 1/3 NS 1 liter bag. How many ml of 23.4% NaCl would you need? (Molecular weight of Na is 23 and Cl is 35.5)

Options:

A.  

12.82ml B. 16.82ml

B.  

23.4ml

C.  

58.5ml

D.  

10ml

Discussion 0
Questions 10

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?

Options:

A.  

Meropenem

B.  

Vancomycin

C.  

Ciprofloxacin

D.  

Sulfamethoxazole/trimethoprim

E.  

Cefepime

Discussion 0
Questions 11

Select the class of Anti-diabetic medication that works in the specified organ to prevent hyperglycemia. Select all that applies. Alpha cells in pancreases

Options:

A.  

Sulfonylureas

B.  

Alpha- Glucosidase Inhibitors

C.  

DPP4 Inhibitors

D.  

Glucagon-like peptide-1 receptor agonists

E.  

Thiazolidinediones

F.  

Biguanide

G.  

SGLT2 inhibitors

Discussion 0
Questions 12

Which of the following NSAIDs is an Enolic acid derivative?

Options:

A.  

Ibuprofen

B.  

Piroxicam

C.  

Naproxen

D.  

Oxaprozin

E.  

Fenoprofen

Discussion 0
Questions 13

Injectable Sulfamethoxazole/Trimethoprim comes as 400mg/80mg/5ml. Physician requests you to dose a Sulfamethoxazole/Trimethoprim intravenously for PCP. You know the dose is 15mg/kg/day (based on TMP component) divided q6h.

How many milliliters of Sulfamethoxazole/Trimethoprim of 400mg/80mg/5ml would you need for single dose? Patient weighs 80kg.

Options:

A.  

18.75 mL

B.  

75 mL

C.  

15 mL

D.  

50 mL

E.  

16.5 mL

Discussion 0
Questions 14

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA.

His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includes Dexamethasone 8mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V, Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn for constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mg po bid, D51/2NS with 20K at 125 mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose 0.1 mg. lock- out every 6min, one hour limit 2.2 mg/hour. Pertinent morning labs includes serum creatinine 1.4 mg/dl, Mg 1.5 mg/dl, K 5.0 mmol/L, Na 135 mmol/L.

Which of the following medication may increase LN’s potassium?

Options:

A.  

Ondansetron

B.  

Metoclopramide

C.  

Metformin

D.  

Lisinopril

E.  

Hydromorphone

Discussion 0
Questions 15

LT is a 42-year-old white female with past medical history of epilepsy, gastroesophageal reflux disease and seasonal allergies. She weighs 86 kg, height 5’6” and allergic to Aspirin (rash) and Phenobarbital (difficulty breathing).

Her medications include Omeprazole 40mg daily, Phenytoin 200mg twice daily, Valproic acid 500mg four times daily, Loratadine 10mg daily. She comes to your community pharmacy to pick up prescription for Primidone 250mg twice daily.

Pertaining to Primidone what is the most appropriate action to take?

Options:

A.  

Notify the physician, Primidone dose is too low.

B.  

Notify the physician, Primidone in contraindicated in patient with phenobarbital allergy.

C.  

Notify the physician, Primidone in contraindicated in patient with Aspirin allergy.

D.  

Notify the physician, patient is already on three anti-seizure medication and primidone is not needed.

E.  

Notify the physician, Primidone in contraindicated in patient with gastroesophageal reflux disease.

Discussion 0
Questions 16

Which of the following is true regarding extent of absorption of drugs?

Options:

A.  

After oral ingestion of drugs, the absorption of drug may be incomplete

B.  

Drugs which are too lipophilic cannot cross the lipid cell membrane

C.  

Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

D.  

P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

E.  

Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

Discussion 0
Questions 17

A 49-year-old’s blood test results have come back from the lab. Their chloride level currently measures 99 mEq/L. How should you interpret this result?

Options:

A.  

Very low, requires immediate treatment

B.  

Slightly below normal

C.  

Within the normal range

D.  

Very high, requires immediate treatment

Discussion 0
Questions 18

Your patient, a 25-year-old G1P0 female at 26 weeks gestation presents due to an abnormal glucose tolerance test. One week prior, she was given 50 g of oral glucose and demonstrate a venous plasma glucose level of 156 mg/dL one hour later.

Which of the following is the most appropriate next step of management?

Options:

A.  

Repeat the 50 g oral glucose challenge

B.  

Administer an oral, 3-hour 100 g glucose dose

C.  

Advise the patient to follow an American Diabetic Association diet plan

D.  

Begin insulin treatment

E.  

Order a fetal ultrasound examination

Discussion 0
Questions 19

What is the standard loading dose for clopidogrel in the treatment of ACS?

Options:

A.  

75mg

B.  

100mg

C.  

150mg

D.  

200mg

E.  

300mg

Discussion 0
Questions 20

Results from a Meta-analysis where they looked at frequency of postoperative arterial fibrillation in patients on Ascorbic acid after cardiac surgery found odds ratio, 0.44 (95% CI, 0.32 to 0.61). How can you interpret this data?

Options:

A.  

Ascorbic acid increased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

B.  

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

C.  

There was no statistically significant difference in frequency of postoperative arterial fibrillation after cardiac surgery

D.  

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 56%

E.  

None of the above are correct

Discussion 0
Questions 21

The rate that an outcome will occur given a particular exposure, compared to the rate of the outcome occurring in the absence of that exposure is definition of which of the following?

Options:

A.  

Incidence rate

B.  

Prevelance rate

C.  

Odds ratio

D.  

Relative risk

E.  

Confidence Interval

Discussion 0
Questions 22

According to the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to ReduceAtherosclerotic Cardiovascular Risk in Adults, which of the following LDL cholesterol thresholds is an indication for high- intensity statin therapy?

Options:

A.  

≥ 100 mg/dL

B.  

≥ 130 mg/dL

C.  

≥ 190 mg/dL

D.  

≥ 200 mg/dL

E.  

≥ 150 mg/dL

Discussion 0
Questions 23

JK is a 67 years old African American man who presents to your clinic for his blood pressure management. His past medical history includes Peptic ulcer disease and hypertension. His two BP readings are 160/98, 159/96 and HR 85. He says he has been adherent to his medication and lifestyle. He currently takes 12.5mg Chlorthalidone and Prilosec 20mg daily.

Which of the following is the best strategy to manage his blood pressure?

Options:

A.  

Increase chlorthalidone to 25mg daily

B.  

Add Norvasc 2.5 daily

C.  

Add Lisinopril 5mg daily

D.  

Add hydrochlorothiazide 25mg daily

E.  

Add Lisinopril 20mg daily

Discussion 0