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Pharmacy Technician Certification (CPhT) Exam Question and Answers

Pharmacy Technician Certification (CPhT) Exam

Last Update Nov 30, 2025
Total Questions : 313

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Questions 1

Federal law restricts the OTC sale of:

Options:

A.  

Loratadine

B.  

Pseudoephedrine

C.  

Acetaminophen

D.  

Naproxen

Discussion 0
Questions 2

According to the manufacturer, Risperdal Consta remains stable at room temperature for a maximum of:

Options:

A.  

12 hours

B.  

7 days

C.  

14 days

D.  

21 days

Discussion 0
Questions 3

Upon receipt of a recall notice, a pharmacy technician should first:

Options:

A.  

call any affected patients.

B.  

put the recall notice in the inventory technician's box for processing.

C.  

check whether the pharmacy has the recalled product in stock.

D.  

send the product back.

Discussion 0
Questions 4

Which of the following medications is available only with a prescription?

Options:

A.  

Pantoprazole

B.  

Omeprazole

C.  

Lansoprazole

D.  

Esomeprazole

Discussion 0
Questions 5

Which of the following medications is commercially available as both an oral tablet and an injection solution?

Options:

A.  

Phenobarbital

B.  

Paroxetine

C.  

Pioglitazone

D.  

Pramipexole

Discussion 0
Questions 6

Retin-A should be stored with the:

Options:

A.  

Liquid preparations.

B.  

Chemotherapy drugs.

C.  

Refrigerated drugs.

D.  

Topical preparations.

Discussion 0
Questions 7

Which of the following medications is commercially available as an oral suspension that remains stable for a maximum of 10 days after reconstitution?

Options:

A.  

Methylphenidate

B.  

Famotidine

C.  

Azithromycin

D.  

Vancomycin

Discussion 0
Questions 8

Federal law restricts the OTC sale of:

Options:

A.  

Loratadine

B.  

Pseudoephedrine

C.  

Acetaminophen

D.  

Naproxen

Discussion 0
Questions 9

According to federal law, a reverse distributor must issue a DEA Form 222 or electronic equivalent to a pharmacy requesting destruction of:

Options:

A.  

acetaminophen with codeine

B.  

hydrocodone with acetaminophen

C.  

promethazine with codeine

D.  

pseudoephedrine with ibuprofen

Discussion 0
Questions 10

Vistarilis a brand name for:

Options:

A.  

Prochlorperazine

B.  

Meclizine

C.  

Ranolazine

D.  

Hydroxyzine

Discussion 0
Questions 11

Therapeutic equivalence (TE) codesmay be found in:

Options:

A.  

Remington: The Science and Practice of Pharmacy.

B.  

The Orange Book.

C.  

Safety Data Sheets (SDSs).

D.  

The package insert.

Discussion 0
Questions 12

A patient presents the following prescription:

Lisinopril 20 mg tablets

Take 1 tab PO q8h

#30 with 12 refills

In order to fill this prescription, the pharmacy must clarify the:

Options:

A.  

directions for use.

B.  

medication strength.

C.  

route of administration.

D.  

number of refills.

Discussion 0
Questions 13

FDA guidelines for Class III drug recallsrequire pharmacies to:

Options:

A.  

Post signs throughout the pharmacy announcing the recall

B.  

Remove from stock all medication that meets the recall specifications

C.  

Notify physicians and all affected personnel of the recall

D.  

Contact all patients who have received medication that meets the recall specifications

Discussion 0
Questions 14

Clopidogrel is indicated to reduce the rate of:

Options:

A.  

Myocardial infarction

B.  

Gastroesophageal reflux

C.  

Chronic migraines

D.  

Type 2 diabetes

Discussion 0
Questions 15

A medication's stability may be affected by factors such as:

Options:

A.  

allergies.

B.  

equivalence.

C.  

oxygen.

D.  

indications.

Discussion 0
Questions 16

Lorazepam oral concentrate should be stored in a pharmacy under the sametemperature conditions as:

Options:

A.  

Lamictal chewable tablets.

B.  

Lanoxin oral solution.

C.  

Lyumjev KwikPen.

D.  

Lunesta tablets.

Discussion 0
Questions 17

According to theFDA,heparin strength per total volumeshould be the primary and prominent expression on the manufacturer’s label, followed by the:

Options:

A.  

Percentage weight per volume

B.  

Volume per total strength

C.  

Strength per mL enclosed in parentheses

D.  

mL per dose enclosed in parentheses

Discussion 0
Questions 18

The administration of ciprofloxacin tablets with milk could cause the inhibition of what pharmacokinetic process?

Options:

A.  

Absorption

B.  

Distribution

C.  

Metabolism

D.  

Excretion

Discussion 0
Questions 19

Behind-the-counter decongestant products containingpseudoephedrinemust be used with caution in patients with:

Options:

A.  

Asthma

B.  

Hypertension

C.  

Hypokalemia

D.  

Eczema

Discussion 0
Questions 20

Which of the following statements regardingspecific patient medication returns in the hospital settingis correct?

Options:

A.  

Unlabeled medications may be dispensed by the nurse at discharge.

B.  

Unopened units-of-use returned from outpatients may be redispensed.

C.  

Unopened units-of-use returned from inpatients may be redispensed.

D.  

Crediting of unused doses is not feasible.

Discussion 0
Questions 21

Which of the following medications should be dispensed with a calibrated oral syringe?

Options:

A.  

Enoxaparin sodium

B.  

Albuterol/ipratropium

C.  

Lorazepam concentrate

D.  

Polyethylene glycol 3350

Discussion 0
Questions 22

Themost effectiveway toprevent the spread of infectionwithin a pharmacy is to:

Options:

A.  

Wear powdered latex gloves.

B.  

Clean counting trays after use.

C.  

Put on shoe covers.

D.  

Wash hands for 30 seconds.

Discussion 0
Questions 23

Which of the following drugs must be dispensed with a patient package insert?

Options:

A.  

Sulfamethoxazole/Trimethoprim

B.  

Norethindrone/Ethinyl Estradiol

C.  

Triamterene/HCTZ

D.  

Emtricitabine/Tenofovir Disoproxil

Discussion 0
Questions 24

If atoxic materialcomes in contact with theskin or eyes, the immediate response should be to:

Options:

A.  

Write an incident report and notify the supervisor

B.  

Call 911 and place an ice bag on the affected area

C.  

Wash the affected area thoroughly with soapy water

D.  

Flush the affected area with large volumes of water

Discussion 0
Questions 25

According to United States Pharmacopeia (USP) standards, a drug with an expiration date of 3/2025 should only be used by the patient through:

Options:

A.  

February 28, 2025

B.  

March 1, 2025

C.  

March 31, 2025

D.  

March 1, 2026

Discussion 0
Questions 26

Which of the following questions from a nurse must be referred to a pharmacist?

Options:

A.  

"What is the generic name for the antibiotic the prescriber wrote?"

B.  

"What is the schedule for my patient's IV antibiotic?"

C.  

"Can I piggyback my patient’s IV antibiotic with her heparin drip?"

D.  

"Does the IV antibiotic require prior authorization from my patient's insurance?"

Discussion 0
Questions 27

Which of the following medications is subject to a Risk Evaluation and Mitigation Strategy (REMS) program?

Options:

A.  

Xarelto

B.  

Suboxone

C.  

Warfarin

D.  

Haloperidol

Discussion 0
Questions 28

"NS" refers to which of the following products?

Options:

A.  

0.45% sodium chloride solution

B.  

0.9% sodium chloride solution

C.  

23.4% sodium chloride solution

D.  

Any solution of sodium chloride in sterile water

Discussion 0
Questions 29

What is the generic name for Lipitor?

Options:

A.  

Provastatin

B.  

Fluvastatin

C.  

Simvastatin

D.  

Atorvastatin

Discussion 0
Questions 30

A prescription foracetaminophen 325 mg tabletswas inadvertently filled withacetaminophen 500 mg tablets, but the verifying pharmacist caught and corrected the mistake before dispensing. It would be most appropriate to report this situation as a(n):

Options:

A.  

Near miss.

B.  

Adverse drug reaction.

C.  

Drug allergy.

D.  

Sentinel event.

Discussion 0
Questions 31

According to federal law, the receiving pharmacy must note which of the following on a transferred controlled substance prescription?

Options:

A.  

The date of the original dispensing

B.  

The medication's expiration date

C.  

The prescriber's DEA number

D.  

The receiving pharmacy's DEA number

Discussion 0
Questions 32

If 120 g of cream contains 3 g of drug, how many g of drug are in 2 oz of cream?

Options:

A.  

1.5

B.  

6

C.  

15

D.  

60

Discussion 0
Questions 33

If 120 g of cream contains 3 g of drug, how many g of drug are in 2 oz of cream?

Options:

A.  

1.5

B.  

6

C.  

15

D.  

60

Discussion 0
Questions 34

According to the Centers for Disease Control and Prevention (CDC), handwashing helps prevent illness because:

Options:

A.  

pathogens are often transferred through touch.

B.  

viruses accumulate on hands in lesser concentrations.

C.  

microorganisms on hands weaken the immune system.

D.  

antibiotic-resistant bacteria can only be removed by hand sanitizer.

Discussion 0
Questions 35

Which of the following medications usually end in "-pril" and are used torelax blood vessels?

Options:

A.  

Beta blockers

B.  

Calcium channel blockers

C.  

ACE inhibitors

D.  

Statins

Discussion 0
Questions 36

Which of the following is anantipsychotic?

Options:

A.  

Aripiprazole

B.  

Rifampin

C.  

Ketoconazole

D.  

Zolpidem

Discussion 0
Questions 37

A prescriber orders1000 mgof a medication. If the stock bottle label stateseach tablet contains 0.1 g, how many tablets should the patient receive?

Options:

A.  

1

B.  

10

C.  

100

D.  

1000

Discussion 0
Questions 38

Which of the following should be taken on anempty stomach?

Options:

A.  

Levothyroxine

B.  

Amlodipine

C.  

Cyclobenzaprine

D.  

Loratadine

Discussion 0
Questions 39

Which of the following medications is subject to a Risk Evaluation and Mitigation Strategy (REMS) program because current patients should avoid becoming pregnant?

Options:

A.  

Creon

B.  

CellCept

C.  

Celexa

D.  

Cialis

Discussion 0
Questions 40

Levetiracetam is a(n):

Options:

A.  

Antibiotic

B.  

Antihyperglycemic

C.  

Anticonvulsant

D.  

Antihypertensive

Discussion 0
Questions 41

Ahazardous drug spill kitfor pharmacy use should include:

Options:

A.  

Permeable, disposable protective garments.

B.  

Sufficient supplies to absorb a spill of about 10,000 mL.

C.  

Reusable absorbent sponges or toweling.

D.  

A disposable scoop for glass fragments.

Discussion 0
Questions 42

A prescription for 1 pint of rifampin 1% suspension. 2 tbsp daily, will be compounded using how many 300 mg capsules of the drug?

Options:

A.  

8

B.  

16

C.  

32

D.  

160

Discussion 0
Questions 43

A prescription reads:

Famotidine 40 mg/5 mL

Quantity: 50 mL

Sig: 0.4 mL PO t.i.d.

What amount of medication, in mg, is given each day?

Options:

A.  

1.2 mg

B.  

3.2 mg

C.  

6.4 mg

D.  

9.6 mg

Discussion 0
Questions 44

A prescription calls foramoxicillin 500 mg PO t.i.d.Which of the following must be provided by the prescriber in order for the prescription to be filled?

Options:

A.  

Therapy duration

B.  

Contraindications

C.  

Auxiliary warnings

D.  

Brand name

Discussion 0
Questions 45

Which of the following is a method that can reduce the likelihood ofdispensing an expired medication?

Options:

A.  

Verifying each lot number.

B.  

Using the newest medications first.

C.  

Rotating stock on a regular basis.

D.  

Using the last in, first out method.

Discussion 0
Questions 46

According to theInstitute for Safe Medication Practices (ISMP), IVpropranololis considered ahigh-alert medicationinacute care settingsbecause it is a(n):

Options:

A.  

Adrenergic antagonist.

B.  

Chemotherapeutic agent.

C.  

Opioid.

D.  

Anticoagulant.

Discussion 0
Questions 47

AMedication Guidemust be dispensed with:

Options:

A.  

Atenolol

B.  

Bupropion

C.  

Diltiazem

D.  

Levothyroxine

Discussion 0
Questions 48

Nurtec ODT must be stored in the original packaging until ready to use because it is sensitive to:

Options:

A.  

moisture

B.  

light

C.  

heat

D.  

cold

Discussion 0
Questions 49

Counting trays should be cleaned frequently to:

Options:

A.  

Eliminate decontamination

B.  

Remove residue

C.  

Guarantee aseptic technique

D.  

Promote allergic reactions

Discussion 0
Questions 50

What volume, inmL, of morphine sulfate that comes in10 mL vials at a concentration of 5 mg/mLwill be needed to fill an order for25 mg?

Options:

A.  

0.5

B.  

2

C.  

2.5

D.  

5

Discussion 0
Questions 51

What is the w/w percentage strength of a zinc oxide ointment compounded by mixing 4.5 g of zinc oxide powder with enough ointment to obtain 30 g of final product?

Options:

A.  

0.25%

B.  

10%

C.  

15%

D.  

17.5%

Discussion 0
Questions 52

According toUSP, the breaking or separation of an oil phase that is not easily dispersed is indicative of a reaction in a(n):

Options:

A.  

Tincture

B.  

Solution

C.  

Suspension

D.  

Emulsion

Discussion 0
Questions 53

Handling hazardous substances should be done:

Options:

A.  

In a chemical safety cabinet.

B.  

Wearing personal protective equipment.

C.  

Using disposable gloves washed between each use.

D.  

In a positive-pressure clean room.

Discussion 0
Questions 54

The generic forNasonexis:

Options:

A.  

Mometasone furoate

B.  

Loteprednol etabonate

C.  

Desloratadine

D.  

Fluticasone

Discussion 0
Questions 55

Incompatibility of a nonsterile compound may be indicated by:

Options:

A.  

a clear solution

B.  

the use of a pH buffer system

C.  

an unexpected change in odor

D.  

suspension particles settling to the bottom of a container

Discussion 0
Questions 56

To decrease the risk of incorrectly filling a prescription for a drug that has a look-alike/sound-alike name, the pharmacy could:

Options:

A.  

use both the brand name and the generic name on the prescription label.

B.  

place the drug next to another look-alike/sound-alike drug on the shelf if they are alphabetical.

C.  

review the first five digits of the NDC to confirm the correct product.

D.  

take hazardous drug precautions.

Discussion 0
Questions 57

When used on a prescription, "SL" refers to a specific:

Options:

A.  

Package size

B.  

Route of administration

C.  

Medication strength

D.  

Disease state

Discussion 0
Questions 58

During final verification, a pharmacist identifies that a prescription written for ampicillin was entered as amoxicillin. The pharmacist corrects the error and the patient receives the prescribed ampicillin. This situation may be reported as a(n):

Options:

A.  

near miss

B.  

dispensing error

C.  

adverse event

D.  

unauthorized drug

Discussion 0
Questions 59

A patient picking up a prescription for lisinopril should be directed to the pharmacist if they:

Options:

A.  

complain of a dry, hacking cough.

B.  

purchase fexofenadine for seasonal allergies.

C.  

mention that they have lowered their cholesterol.

D.  

report that their blood pressure has been normal lately.

Discussion 0
Questions 60

Which of the followingmedications should be pulled from inventorydue to incorrect storage?

Options:

A.  

Boostrix that was stored in a refrigerator.

B.  

Havrix that was stored in a refrigerator.

C.  

Shingrix that was stored in a freezer.

D.  

Varivax that was stored in a freezer.

Discussion 0
Questions 61

According to theDEA, how often must aphysical inventory of all controlled substancesbe performed?

Options:

A.  

Once a month

B.  

Every six months

C.  

Once a year

D.  

Every two years

Discussion 0
Questions 62

Which of the following auxiliary labels would be most appropriate to affix to a bottle ofcephalexin oral suspensionafter reconstitution?

Options:

A.  

Protect from light; Discard after 7 days

B.  

Protect from light; Discard after 14 days

C.  

Keep refrigerated; Discard after 7 days

D.  

Keep refrigerated; Discard after 14 days

Discussion 0
Questions 63

If a prescription for amoxicillin 150 mg PO q8h for 10 days is filled with a 250 mg/5 mL suspension, how many mL would the patient take per dose?

Options:

A.  

3

B.  

4

C.  

5

D.  

6

Discussion 0
Questions 64

Addyi is subject to a Risk Evaluation and Mitigation Strategy (REMS) program because it:

Options:

A.  

can cause severe hypotension and syncope.

B.  

is an emergency oral contraceptive.

C.  

contains an opioid analgesic.

D.  

is a monoclonal antibody.

Discussion 0
Questions 65

A medication quantity was omitted from a prescription. This occurrence may best be described as which type of error?

Options:

A.  

Administration

B.  

Dispensing

C.  

Dosage

D.  

Prescribing

Discussion 0
Questions 66

According to USP, which of the following may be used todecontaminate human skin?

Options:

A.  

Antibiotics

B.  

Antiseptics

C.  

Chemical sterilants

D.  

UV irradiation

Discussion 0
Questions 67

Which of the following suppositories should be shipped to the pharmacy in arefrigerated container?

Options:

A.  

Promethazine

B.  

Prochlorperazine

C.  

Hydrocortisone

D.  

Bisacodyl

Discussion 0
Questions 68

Potassium chloride for injection is considered high-alert in acute care settings because:

Options:

A.  

It has a look-alike/sound-alike medication name.

B.  

The packaging uses different colors for different strengths.

C.  

Prescribers prefer a different medication for similar indications.

D.  

It is likely to cause severe harm to patients if used in error.

Discussion 0
Questions 69

Oxybutynin is indicated to treat symptoms associated with:

Options:

A.  

Bronchitis

B.  

Hyperlipidemia

C.  

Overactive bladder

D.  

Pancreatitis

Discussion 0
Questions 70

Aspacerwas prescribed to accompany ametered dose inhaler (MDI), but the patient never picked it up. The spacer should be returned to:

Options:

A.  

Damaged stock

B.  

The manufacturer

C.  

The study sponsor

D.  

Dispensing stock

Discussion 0
Questions 71

According to the FDA, a Medication Guide must be given to the patient when dispensing:

Options:

A.  

zafirlukast.

B.  

Zestril.

C.  

zinc.

D.  

Zyprexa.

Discussion 0
Questions 72

Due to a drug-drug interaction, patients taking tetracycline should avoid simultaneous use of:

Options:

A.  

antacids that contain calcium.

B.  

decongestants that contain pseudoephedrine.

C.  

antitussives that contain dextromethorphan.

D.  

analgesics that contain acetaminophen.

Discussion 0
Questions 73

Eliquis is considered ahigh-alert medicationbecause it can cause potentially fatal:

Options:

A.  

Respiratory depression

B.  

Bleeding

C.  

Hyperglycemia

D.  

Hypoxia

Discussion 0
Questions 74

According to federal law, pharmacies must use controlled substance ordering to receive stock bottles of which of the following medications?

Options:

A.  

Buspirone

B.  

Nortriptyline

C.  

Methadone

D.  

Sildenafil

Discussion 0
Questions 75

While unpacking today's shipment, a pharmacy technician notices that a vial of Apidra arrived frozen. The technician's best course of action is to prepare the item to be:

Options:

A.  

thawed and stored in a refrigerator

B.  

sent to the prescriber

C.  

dispensed to a patient

D.  

returned to the distributor

Discussion 0
Questions 76

An order for furosemide 120 mg IV STAT will be dispensed using furosemide 40 mg/2 ml. What volume, in ml of the stock injection will be required to deliver the requested dose?

Options:

A.  

1

B.  

3

C.  

6

D.  

12

Discussion 0
Questions 77

Retin-A should be stored with the:

Options:

A.  

Liquid preparations.

B.  

Chemotherapy drugs.

C.  

Refrigerated drugs.

D.  

Topical preparations.

Discussion 0
Questions 78

Which of the following is an OTC medication indicated to treat motion sickness?

Options:

A.  

Meclizine

B.  

Olanzapine

C.  

Promethazine

D.  

Scopolamine

Discussion 0
Questions 79

ReconstitutedArexvymust be discarded if it is not used within a maximum of:

Options:

A.  

30 minutes

B.  

4 hours

C.  

24 hours

D.  

1 week

Discussion 0
Questions 80

Which of the following medication pairs is an example of aLook-Alike, Sound-Alike (LASA) errorin which an antifungal drug is dispensed instead of an anesthetic drug?

Options:

A.  

Diflucan and Diprivan

B.  

Clonidine and Klonopin

C.  

Metronidazole and Metformin

D.  

Amiloride and Amlodipine

Discussion 0
Questions 81

A patient picking up a prescription for lisinopril should be directed to the pharmacist if they:

Options:

A.  

complain of a dry, hacking cough.

B.  

purchase fexofenadine for seasonal allergies.

C.  

mention that they have lowered their cholesterol.

D.  

report that their blood pressure has been normal lately.

Discussion 0
Questions 82

Which of the following medications is subject to a Risk Evaluation and Mitigation Strategy (REMS) program because current patients should avoid becoming pregnant?

Options:

A.  

Sertraline

B.  

Ondansetron

C.  

Montelukast

D.  

Mycophenolate

Discussion 0
Questions 83

What volume (in mL) of adexamethasone injection (20 mg/mL)is required to administer a30 mg dose?

Options:

A.  

0.15

B.  

0.67

C.  

1.5

D.  

6.7

Discussion 0
Questions 84

If M-M-R II antigen were inadvertently reconstituted with a stock vial of normal saline, pharmacy staff should:

Options:

A.  

administer the vaccine as the diluents are equivalent.

B.  

report the incident to the Drug Enforcement Administration (DEA).

C.  

contact the Environmental Protection Agency (EPA) for guidance.

D.  

discard the vaccine as its efficacy could be altered.

Discussion 0
Questions 85

If250 mL of a 15% solutionis diluted to1.2 L, what is the resulting percentage strength?

Options:

A.  

0.72%

B.  

3.1%

C.  

3.6%

D.  

72%

Discussion 0
Questions 86

According toUSP Chapter 800, a reusable counting tray used to count outcyclophosphamidecapsules must be:

Options:

A.  

Activated before each use.

B.  

Disposed of after each use.

C.  

Decontaminated after each use.

D.  

Sterilized before each use.

Discussion 0
Questions 87

The use of Tall Man lettering:

Options:

A.  

highlights the similarities in drug names.

B.  

ensures all trade names will be capitalized.

C.  

draws attention to the differences in drug names.

D.  

keeps the pharmacy inventory in alphabetic order.

Discussion 0
Questions 88

Which of the following over-the-counter pain medications would be most appropriate for a patient with gastroesophageal reflux disease?

Options:

A.  

Naproxen

B.  

Acetaminophen

C.  

Ibuprofen

D.  

Aspirin

Discussion 0
Questions 89

What is the first thing a pharmacy technician should do when a body area is exposed to a hazardous substance?

Options:

A.  

Notify the pharmacy manager

B.  

Thoroughly flush with water

C.  

Call environmental services for help with cleanup

D.  

Go to the emergency department

Discussion 0
Questions 90

A company that is able to receive and dispose of expired medications from a pharmacy is called a:

Options:

A.  

Secondary wholesaler.

B.  

Cancer drug repository.

C.  

Reverse distributor.

D.  

Prime vendor.

Discussion 0
Questions 91

A patient presents the following prescription:

Amoxicillin 250 mg/5 mL

1 tsp tid x 10 days

How much of the medication, in mL, will be used during the first 5 days of therapy?

Options:

A.  

25

B.  

50

C.  

75

D.  

150

Discussion 0
Questions 92

According to the Institute for Safe Medication Practices (ISMP), which of the following is an example of a look-alike/sound-alike medication pair?

Options:

A.  

Desipramine and desmopressin

B.  

Chlordiazepoxide and chlorpromazine

C.  

Fluoxetine and fluticasone

D.  

Humalog and Humira

Discussion 0
Questions 93

A patient who has been receiving cimetidine 400 mg one tablet b.i.d. is switched to the liquid, which is available as 300 mg/5 mL. The volume of solution, in mL, required for each dose is:

Options:

A.  

1.3

B.  

6.7

C.  

7.6

D.  

13.3

Discussion 0