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Pharmacy Technician Certification (CPhT) Exam Question and Answers

Pharmacy Technician Certification (CPhT) Exam

Last Update Oct 15, 2025
Total Questions : 238

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Questions 1

According to theInstitute for Safe Medication Practices (ISMP), IVpropranololis considered ahigh-alert medicationinacute care settingsbecause it is a(n):

Options:

A.  

Adrenergic antagonist.

B.  

Chemotherapeutic agent.

C.  

Opioid.

D.  

Anticoagulant.

Discussion 0
Questions 2

Adult and pediatric strengths of the same vaccine are often packaged similarly.As a safety precaution, theCDCrecommends that pharmacies do which of the following?

Options:

A.  

Remove vaccines from the original packaging and repackage

B.  

Order each strength from different manufacturers

C.  

Store each strength in different locations within the storage unit

D.  

Make products available only in an automated dispensing system

Discussion 0
Questions 3

Medications considered to have a narrow therapeutic index generally exhibit a(n):

Options:

A.  

shorter window of guaranteed stability.

B.  

incompatibility with therapeutic monitoring.

C.  

synergistic effect on other medications.

D.  

higher risk of causing serious toxicity.

Discussion 0
Questions 4

A physician prescribes5 mg/kgof a drugtwice dailyfor a patient weighing110 lbs. How many0.5 g tabletsof the drug are required for a10-day duration?

Options:

A.  

5

B.  

10

C.  

20

D.  

40

Discussion 0
Questions 5

A prescription specifiesalbuterol (containing 200 MDI) at 2 puffs q6h PRN.The medication will last a minimum of:

Options:

A.  

10 days

B.  

14 days

C.  

25 days

D.  

30 days

Discussion 0
Questions 6

If 120 g of cream contains 3 g of drug, how many g of drug are in 2 oz of cream?

Options:

A.  

1.5

B.  

6

C.  

15

D.  

60

Discussion 0
Questions 7

The generic forNasonexis:

Options:

A.  

Mometasone furoate

B.  

Loteprednol etabonate

C.  

Desloratadine

D.  

Fluticasone

Discussion 0
Questions 8

Which of the following medications is indicated to treat mild, moderate, or severe dementia of the Alzheimer type?

Options:

A.  

Aricept

B.  

Azilect

C.  

Ambien

D.  

Atacand

Discussion 0
Questions 9

St. John's Wort is primarily used as a(n):

Options:

A.  

immune enhancer

B.  

mild antidepressant

C.  

antioxidant

D.  

antihypertensive

Discussion 0
Questions 10

Which of the following medications is available in both oral and injectable dosage forms?

Options:

A.  

Ketorolac

B.  

Dobutamine

C.  

Benzonatate

D.  

Cefazolin

Discussion 0
Questions 11

Asyndrome that can be produced by abrupt cessation or rapid dose reduction of a medicationis:

Options:

A.  

Tolerance

B.  

Addiction

C.  

Withdrawal

D.  

Dependency

Discussion 0
Questions 12

"NS" refers to which of the following products?

Options:

A.  

0.45% sodium chloride solution

B.  

0.9% sodium chloride solution

C.  

23.4% sodium chloride solution

D.  

Any solution of sodium chloride in sterile water

Discussion 0
Questions 13

FDA guidelines for Class III drug recallsrequire pharmacies to:

Options:

A.  

Post signs throughout the pharmacy announcing the recall

B.  

Remove from stock all medication that meets the recall specifications

C.  

Notify physicians and all affected personnel of the recall

D.  

Contact all patients who have received medication that meets the recall specifications

Discussion 0
Questions 14

Medications’lot numbersare assigned by the:

Options:

A.  

Food and Drug Administration (FDA).

B.  

Drug Enforcement Administration (DEA).

C.  

Wholesaler.

D.  

Manufacturer.

Discussion 0
Questions 15

Whichvitaminshould be takenbefore and during pregnancyto help avoidneural tube defects?

Options:

A.  

Pyridoxine

B.  

Ascorbic acid

C.  

Thiamine

D.  

Folic acid

Discussion 0
Questions 16

How many2 oz bottlescan be filled if100 mL of a 20% solutionis diluted to make a2% solution?

Options:

A.  

10

B.  

16

C.  

27

D.  

33

Discussion 0
Questions 17

According to the manufacturer, which of the following medications must be dispensed in its original container?

Options:

A.  

Furosemide

B.  

Linaclotide

C.  

Valsartan

D.  

Sertraline

Discussion 0
Questions 18

Themost effectiveway toprevent the spread of infectionwithin a pharmacy is to:

Options:

A.  

Wear powdered latex gloves.

B.  

Clean counting trays after use.

C.  

Put on shoe covers.

D.  

Wash hands for 30 seconds.

Discussion 0
Questions 19

According to NIOSH, pharmacy staff should wear appropriate personal protective equipment (PPE) when handling crushed or broken tablets of:

Options:

A.  

megestrol and dutasteride

B.  

furosemide and buspirone

C.  

glyburide and acetazolamide

D.  

glipizide and zolpidem

Discussion 0
Questions 20

A prescription calls foramoxicillin 500 mg PO t.i.d.Which of the following must be provided by the prescriber in order for the prescription to be filled?

Options:

A.  

Therapy duration

B.  

Contraindications

C.  

Auxiliary warnings

D.  

Brand name

Discussion 0
Questions 21

What is the w/w percentage strength of a zinc oxide ointment compounded by mixing 4.5 g of zinc oxide powder with enough ointment to obtain 30 g of final product?

Options:

A.  

0.25%

B.  

10%

C.  

15%

D.  

17.5%

Discussion 0
Questions 22

According tofederal law, records regarding thedistribution, receipt, or destructionofcontrolled substancesmust be maintained for a minimum ofhow many years?

Options:

A.  

1

B.  

2

C.  

5

D.  

7

Discussion 0
Questions 23

Themiddle series of numbersin theNational Drug Code (NDC)is used for:

Options:

A.  

Identification of therapeutic class

B.  

Locating expired medication on the shelf

C.  

Proper storage of the medication

D.  

Accurate product selection

Discussion 0
Questions 24

According to DEA regulations, invoices for which of the following medications must be filed separately from all other invoices?

Options:

A.  

Lidocaine

B.  

Fentanyl

C.  

Oseltamivir

D.  

Diltiazem

Discussion 0
Questions 25

A prescription foracetaminophen 325 mg tabletswas inadvertently filled withacetaminophen 500 mg tablets, but the verifying pharmacist caught and corrected the mistake before dispensing. It would be most appropriate to report this situation as a(n):

Options:

A.  

Near miss.

B.  

Adverse drug reaction.

C.  

Drug allergy.

D.  

Sentinel event.

Discussion 0
Questions 26

Which of the following medications usually end in "-pril" and are used torelax blood vessels?

Options:

A.  

Beta blockers

B.  

Calcium channel blockers

C.  

ACE inhibitors

D.  

Statins

Discussion 0
Questions 27

Which of the followingSig codesis paired with its correct interpretation?

Options:

A.  

q.s.: shake well

B.  

IN: intramuscular

C.  

AU: both ears

D.  

q.i.d.: three times a day

Discussion 0
Questions 28

Which of the following is considered a high-alert medication in some settings because it is an antiretroviral agent?"

And provides these options:

Options:

A.  

Meperidine

B.  

Olopatadine

C.  

Lamivudine

D.  

Tizanidine

Discussion 0
Questions 29

What volume (in mL) of adexamethasone injection (20 mg/mL)is required to administer a30 mg dose?

Options:

A.  

0.15

B.  

0.67

C.  

1.5

D.  

6.7

Discussion 0
Questions 30

Which of the following needle guages corresponding to the smallest human?

Options:

A.  

13

B.  

18

C.  

20

D.  

27

Discussion 0
Questions 31

Medications considered to have anarrow therapeutic index (NTI)generally exhibita(n):

Options:

A.  

Shorter window of guaranteed stability.

B.  

Incompatibility with therapeutic monitoring.

C.  

Synergistic effect on other medications.

D.  

Higher risk of causing serious toxicity.

Discussion 0
Questions 32

According to theDEA, how often must aphysical inventory of all controlled substancesbe performed?

Options:

A.  

Once a month

B.  

Every six months

C.  

Once a year

D.  

Every two years

Discussion 0
Questions 33

Oxcarbazepine is a(n):

Options:

A.  

bronchodilator

B.  

antiepileptic

C.  

vasodilator

D.  

decongestant

Discussion 0
Questions 34

According to the Centers for Disease Control and Prevention (CDC), pharmacy technicians should wash their hands with soap and water whenever:

Options:

A.  

they have time, before eating, and after eating.

B.  

their hands are visibly clean, after eating, and before each patient.

C.  

they have finished filling prescriptions, before eating, and after each patient.

D.  

their hands are visibly dirty, before eating, and after using the restroom.

Discussion 0
Questions 35

According to federal law, pharmacies must use controlled substance ordering to receive stock bottles of which of the following medications?

Options:

A.  

Buspirone

B.  

Nortriptyline

C.  

Methadone

D.  

Sildenafil

Discussion 0
Questions 36

A local provider has written the following compounded prescription for a patient:

Zinc oxide ointment 20% 60 g

Nystatin ointment 100,000 units/g 60 g

Hydrocortisone ointment 1% 60 g

Cholestyramine powder 10 g

Mineral oil USP 10 mL

Total Weight 200 g

Which of the agents listed is an antifungal agent?

Options:

A.  

Cholestyramine

B.  

Hydrocortisone

C.  

Zinc oxide

D.  

Nystatin

Discussion 0
Questions 37

A patient is prescribed Prilosec capsules for gastroesophageal reflux disease. If thepatient is unable to swallow capsules, they may:

Options:

A.  

open the capsules and sprinkle the medication on applesauce.

B.  

chew and swallow the capsules.

C.  

compound the capsules into a topical preparation.

D.  

allow the capsules to dissolve under their tongue.

Discussion 0
Questions 38

According to theFDA,heparin strength per total volumeshould be the primary and prominent expression on the manufacturer’s label, followed by the:

Options:

A.  

Percentage weight per volume

B.  

Volume per total strength

C.  

Strength per mL enclosed in parentheses

D.  

mL per dose enclosed in parentheses

Discussion 0
Questions 39

Adispensing erroris defined as a discrepancy between a prescription and the medication that is:

Options:

A.  

Requested by the patient.

B.  

On the plan formulary.

C.  

Supplied by the wholesaler.

D.  

Received by the patient.

Discussion 0
Questions 40

An outsourcing facility mislabeled enoxaparin syringes asphytonadione syringesand sent them out to multiple facilities. Which type of recall would be most appropriate to issue?

Options:

A.  

Class I

B.  

Class II

C.  

Class III

D.  

Misbranding

Discussion 0
Questions 41

A pharmacy technician should notify a pharmacist when a refill of sertraline is requested if the patient:

Options:

A.  

presents new insurance coverage.

B.  

requests the refill two days early.

C.  

reports suicidal ideation.

D.  

reports improved interest and motivation.

Discussion 0
Questions 42

Antacids that contain calcium carbonatemay decrease the serum concentration of:

Options:

A.  

Amoxicillin

B.  

Bacitracin

C.  

Cephalexin

D.  

Doxycycline

Discussion 0
Questions 43

Carvedilolmay be a suitable therapeutic substitution for:

Options:

A.  

Albuterol

B.  

Labetalol

C.  

Tramadol

D.  

Estradiol

Discussion 0
Questions 44

Which of the following medications is an anticonvulsant used in the prophylaxis and control of various types of seizures?

Options:

A.  

Clonidine

B.  

Atomoxetine

C.  

Guanfacine

D.  

Phenytoin

Discussion 0
Questions 45

Handling hazardous substances should be done:

Options:

A.  

In a chemical safety cabinet.

B.  

Wearing personal protective equipment.

C.  

Using disposable gloves washed between each use.

D.  

In a positive-pressure clean room.

Discussion 0
Questions 46

Which of the following medications is considered safest for a pregnant patient to use?

Options:

A.  

Isotretinoin

B.  

Acetaminophen

C.  

Lovastatin

D.  

Triazolam

Discussion 0
Questions 47

Which of the followingdeviceswould be most appropriate to dispense for a patient to use with theirAsmanex HFA?

Options:

A.  

A nebulizer

B.  

A spacer

C.  

A ventilator

D.  

A glucometer

Discussion 0
Questions 48

To which drug classification does Cytoxan belong?

Options:

A.  

ACE inhibitor

B.  

Chemotherapy agent

C.  

Antibiotic

D.  

Narcotic

Discussion 0
Questions 49

Which of the following drugs must be dispensed with a patient package insert?

Options:

A.  

Sulfamethoxazole/Trimethoprim

B.  

Norethindrone/Ethinyl Estradiol

C.  

Triamterene/HCTZ

D.  

Emtricitabine/Tenofovir Disoproxil

Discussion 0
Questions 50

Stock rotation is best defined as the:

Options:

A.  

reordering of medications to generate greater turnover

B.  

removal of specific medications that are to be replaced with new product

C.  

number of times medications are purchased, sold, and replaced in any time period

D.  

placement of medications with later expiration dates behind those with earlier expiration dates

Discussion 0
Questions 51

Which of the following medications is aproton pump inhibitor (PPI)?

Options:

A.  

Prilosec

B.  

Prozac

C.  

Paxil

D.  

Plavix

Discussion 0
Questions 52

A pharmacy technician receives a prescription forZyrtec 10 mg once a dayfor schizophrenia. The technician should alert the pharmacist because:

Options:

A.  

Zyrtec requires special handling.

B.  

The prescription exceeds the maximum recommended daily dose.

C.  

The prescription appears to contain a look-alike sound-alike (LASA) error.

D.  

Zyrtec is subject to a REMS program.

Discussion 0
Questions 53

Which of the following should be used tohelp incorporate a solid (like powder) into an ointmentduringnonsterile compounding?

Options:

A.  

Emulsifying agents

B.  

Diluents

C.  

Levigating agents

D.  

Preservatives

Discussion 0
Questions 54

What is the first thing a pharmacy technician should do when a body area is exposed to a hazardous substance?

Options:

A.  

Notify the pharmacy manager

B.  

Thoroughly flush with water

C.  

Call environmental services for help with cleanup

D.  

Go to the emergency department

Discussion 0
Questions 55

The correct direction for a prescription label for the Sig:"2 gtt OU q4-6h p.r.n."is to place two drops in:

Options:

A.  

Both ears every 4 to 6 hours as needed.

B.  

The right ear every 4 to 6 hours as needed.

C.  

The right eye every 4 to 6 hours as needed.

D.  

Both eyes every 4 to 6 hours as needed.

Discussion 0
Questions 56

Which of the following is an event that must be reported to VAERS if it occurs after vaccine administration?

Options:

A.  

Constipation

B.  

Anaphylaxis

C.  

Drowsiness

D.  

Hyperlipidemia

Discussion 0
Questions 57

The label of a stock bottle provides the following information:

(01)55555444422

(1)051526

(10)ABC123

(21)11262026

What is the lot number for this medication?

Options:

A.  

ABC123

B.  

55555444422

C.  

051526

D.  

11262026

Discussion 0
Questions 58

Adsorptionis most likely to cause a medication to:

Options:

A.  

Lose potency.

B.  

Become contaminated.

C.  

Require refrigeration.

D.  

Trigger anaphylaxis.

Discussion 0
Questions 59

The directions for aZ-Pak (azithromycin)specify:

Options:

A.  

1 tablet PO on the current day, then 1 PO daily for 4 days.

B.  

1 tablet PO on the current day, then 1 PO daily for 5 days.

C.  

2 tablets PO on the current day, then 1 PO daily for 4 days.

D.  

3 tablets PO on the current day, then 1 PO every other day for 6 days.

Discussion 0
Questions 60

According to theInstitute for Safe Medication Practices (ISMP),duloxetineis at risk of being confused with the generic name for:

Options:

A.  

Plavix

B.  

Paxil

C.  

Pradaxa

D.  

Pulmicort

Discussion 0
Questions 61

If atoxic materialcomes in contact with theskin or eyes, the immediate response should be to:

Options:

A.  

Write an incident report and notify the supervisor

B.  

Call 911 and place an ice bag on the affected area

C.  

Wash the affected area thoroughly with soapy water

D.  

Flush the affected area with large volumes of water

Discussion 0
Questions 62

What volume, inmL, of morphine sulfate that comes in10 mL vials at a concentration of 5 mg/mLwill be needed to fill an order for25 mg?

Options:

A.  

0.5

B.  

2

C.  

2.5

D.  

5

Discussion 0
Questions 63

TheResource Conservation and Recovery Act (RCRA)considers which of the following to beU-listed hazardous waste?

Options:

A.  

Dorzolamide

B.  

Bicalutamide

C.  

Acetazolamide

D.  

Cyclophosphamide

Discussion 0
Questions 64

How muchmentholis required to compound a formula reading:

    Camphor 0.3%

    Menthol 0.25%

    Hydrocortisone 1%

    Aquaphor q.s. ad 600 g

Options:

A.  

15 mg

B.  

150 mg

C.  

1500 mg

D.  

15 g

Discussion 0
Questions 65

What type ofmedication erroris described asa mistake in prescribing, dispensing, or planned medication administration that is detected and corrected before reaching the patient?

Options:

A.  

Compliance error

B.  

Monitoring error

C.  

Omission error

D.  

Potential error

Discussion 0
Questions 66

ReconstitutedArexvymust be discarded if it is not used within a maximum of:

Options:

A.  

30 minutes

B.  

4 hours

C.  

24 hours

D.  

1 week

Discussion 0
Questions 67

A patient presents the following prescription:

Lisinopril 20 mg tablets

Take 1 tab PO q8h

#30 with 12 refills

In order to fill this prescription, the pharmacy must clarify the:

Options:

A.  

directions for use.

B.  

medication strength.

C.  

route of administration.

D.  

number of refills.

Discussion 0
Questions 68

Addyi is subject to a Risk Evaluation and Mitigation Strategy (REMS) program because it:

Options:

A.  

can cause severe hypotension and syncope.

B.  

is an emergency oral contraceptive.

C.  

contains an opioid analgesic.

D.  

is a monoclonal antibody.

Discussion 0
Questions 69

Behind-the-counter decongestant products containingpseudoephedrinemust be used with caution in patients with:

Options:

A.  

Asthma

B.  

Hypertension

C.  

Hypokalemia

D.  

Eczema

Discussion 0
Questions 70

Where permitted by state regulation, a pharmacy technician may be responsible for:

Options:

A.  

Counseling patients on new prescriptions

B.  

Completing a clinical review of new prescriptions

C.  

Initiating the transfer of non-controlled substance prescriptions

D.  

Approving the validity of controlled substance prescriptions

Discussion 0
Questions 71

Which type of injection administers a medication into theskin?

Options:

A.  

Intraperitoneal

B.  

Intravenous

C.  

Intramuscular

D.  

Intradermal

Discussion 0